About

A three-day scientific symposium bringing together researchers and clinicians from the immunology, bone and gut fields with internationally renowned keynote speakers, orals selected from abstract submissions and poster presentations.

As we continue to unravel the intricate connections within the human body, emerging research has shed light on the fascinating interplay between seemingly disparate systems. Among these connections, the relationship between the gastrointestinal (GI) tract and bone health has emerged as an interesting area of study: the gut-bone axis. 

The gut-bone axis refers to the bidirectional communication and influence between the gut microbiota, its metabolites, and bone metabolism. Over the past decade, a growing body of evidence has highlighted the profound impact of gut health on bone physiology, challenging traditional siled perspectives on these physiological systems. This meeting aims to bring together experts and researchers in different fields to delve into multifaceted aspects of the gut-bone axis. Our primary objectives are the following: 

1. Understand the interaction: 

Explore the intricate relationship between the composition of the gut microbiota, its metabolites and their influence on bone remodeling and density. Study the mechanisms and signaling pathways through which gut-derived factors influence bone health. 

2. Clinical implications: 

Discuss clinical implications and potential therapeutic interventions for bone-related disorders resulting from dysbiosis or gut health disorders. Review current diagnostic tools and methodologies for evaluating the gut-bone axis in clinical settings. 

3. Nutritional factors and lifestyle: 

Examine the role of diet, prebiotics, probiotics, and other lifestyle factors in modulating the gut microbiota and subsequently influencing bone health. 

Explore how lifestyle modifications can be integrated into clinical practice to improve bone outcomes. 

4. Future directions and collaborations: 

Identify gaps in current research and propose avenues for further investigation. Promote collaborations between multidisciplinary teams to improve our understanding of the gut-bone axis and translate findings into clinical practice. 

This meeting aims to serve as a platform to share cutting-edge research, promote interdisciplinary dialogue, and catalyze innovative approaches to address the complex interrelationship between gut and bone health. By bringing together experts in this field, we hope to pave the way for transformative advances in both research and clinical practice.    


Programme

April 17th

Grand Hotel Santa Lucia - Napoli 

 

14:00-14:30

Registration and welcome


Session 1 Capri

Chair: Ranjeny Thomas


14:30-14:50

 Dennis McGonagle 

"Soft-tissue vs bone involvement in the pathogenesis of SpA"


14:50-15:10

Iannis Adamopoulos

“IL-23 as a master immune regulator of bone in SpA”


15:10-15:30

 Discussion


15:30-15:50

Coffee break


Session 2 Positano

Chair: Maria Antonietta D’agostino


15:50-16:10

Joyce Wu

“Aberrant and potent Tfh cells generated by Th17 cell plasticity in the gut promote extra-intestinal autoimmunity”


16:10-16:30

Dana Orange

“Oral Mucosal Breaks as a Trigger for Rheumatoid Arthritis”


16:30-16:50

Discussion


Session 3 Procida

Chair: Dirk Elewaut


16:50-17:10

Martin Kriegel 

“Diet-microbiota-host effects in rheumatic diseases”


17:10-17:30

 Kristine Kuhn

“Antigen dependent and independent mechanisms by which intestinal bacteria contribute to inflammatory arthritis”


17:30-18:00

Discussion and end of the first day


18:00-18:15

Sponsored lecture NO ECM


18:15-18-30

Sponsored lecture NO ECM



April 18th

Grand Hotel Santa Lucia - Napoli 


Session 4 Ischia

Chair: Claudia Mauri


9:00-9:20

Roberto Pacifici

"The gut-bone axis: a key player in transgender medicine, bone metastasis, and fracture repair”


9:20-9:40

Dirk Elewaut

"Feeding the bone through the brain"


9:40-10:00

 Discussion


10:00-10:20

 Coffee break



Session 5 Sorrento

Chair: Georg Schett


10:20-10:40

Maxime Breban

"A journey through the realm of gut microbiota in spondyloarthritis”


10:40-11:00

Claudia Mauri

"Is rheumatoid arthritis a gut-related autoimmune disease?"


11:00-11:20

 Discussion



Session 6 Pompei

Chair: Roberto Caporali


11:20-11:40

Ranjeny Thomas

"Antigen presentation and restoring tolerance in autoimmune rheumatic disease”


11:40-12:00

Diane van der Woude

"Gut as the Origin of the Anti-Modified Protein Antibody Response in Rheumatoid Arthritis"


12:00-12:20

 Discussion


12:20-14:00

Lunch



Young session 1

Chair: Giuliana Guggino


14:00-14:10

Ann-Sophie Bergot

"The role of myeloid cells in the dissemination of bacteria from the gut to the joint in SKG mice ”


14:10-14:20

Gerlando Natalello

"The intestinal epithelial interface in Spondyloarthritis: insights from an Organoid-based model"


14:20-14:30

 Daniele Mauro

"Uterine-joint axis in SpA pathogenesis"


14:30-15:00

Discussion



Young session 2

Chair: Diane van der Woude


15:00-15:10

Eva Schmid

"Spatial cellular analysis of the gut – does the gut vasculature play a role in RA?”


15:10-15:20

Kerstin Dürholz

"Gut-specific H3R signaling orchestrates microglia-dependent resolution of peripheral inflammation"


15:20-15:30

 Carlijn A Wagenaar

"Plants for joints: how does the gut play a role?"


15:30-16:00

Discussion



Young session 3

Chair: Torkell Ellingsen


16:00-16:10

Zuzanna Lukasik 

"It takes guts to research joints”


16:10-16:20

Eric Gracey

"The mechanosensitive transcription factor BHLHE40 controls new bone formation in inflammatory arthritis"


16:20-16:30

 Simon Glatigny

"Ruminococcus gnavus in Spondyloarthritis, story of a commensal killer"


16:30-17:00

Discussion


17:00-17:15

Sponsored lecture NO ECM – Eli Lilly


17:15-17:30

Sponsored lecture NO ECM


17:30-17:45

Sponsored lecture NO ECM


17:45-18:00

Sponsored lecture NO ECM


April 19th

Grand Hotel Santa Lucia - Napoli 


Session 7 Ercolano

Chair: Martin Kriegel


9:00-9:20

Yubin Luo (online)

"The role of neutrophils in the etiology of autoimmune diseases”


9:20-9:40

Alf Kastbom

"Mucosal influence on rheumatoid arthritis development -from risk stratification to disease prevention "


9:40-10:00

 Discussion


10:00-10:20

 Jose Scher

"Psoriatic arthritis from a mechanistic perspective ”


10:20-10:40

Torkell Ellingsen

"Rheumatological perspectives on the microbiome from the lab bench to the health-register ”


10:40-11:00

Discussion


11:00-11:20

 Coffee break



Young session 4

Chair: Kristie Kuhn


11:20-11:30

Giulio Forte

"Neuroinflammation in the pathogenesis of AxSpA”


11:30-11:40

Thomas Macleod

"The two faces of JAK inhibition at the enthesis"


11:40-11:50

 Jose Garrido Mesa

"Characterization of AS-associated autoimmunity links gut and entheseal immunity"


11:50-12:00

Chiara Rizzo

"IL-9 pathway from gut to joints: exploring the GITR/GITRL axis in PsA"


12:00-12:30

Discussion


12:30-13:00

End of works


13:00-14:00

 Light lunch and farewell reception


Speakers

Prof. Dennis McGonagle,

University of Leeds

Prof. Iannis Adamopoulos, Harvard Medical School

Prof. Hsin-Jung Joyce Wu, The Ohio State University

Prof. Dana Orange,

The Rockefeller University

Prof. Martin Kriegel,

Universität Münster

Prof. Kristine Kuhn,

University of Colorado Denver

Prof. Roberto Pacifici,

Emory University School of Medicine

Prof. Dirk Elewaut,

Ghent University

Prof. Claudia Mauri,

University College London

Prof. Ranjeny Thomas,

University of Queensland

Prof. Diane van der Woude,

Leiden University Medical Center

Prof. Yubin Luo,

Sichuan University

Prof. Alf Kastbom,

Linköping Universität

Dr. Jose Scher,

New York University

Prof. Torkell Ellingsen,

University of Southern Denmark

Sponsors

This meeting is generously sponsored by:

GBA Meeting 2024 Registration

REGISTRATION IS OPEN!

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